Bioautographic Analysis And Antibacterial Activity Test Of Mengkudu Leaf (Morinda Citrifolia L.) Ethanol Extract On The Bacteria Propionibacterium Acnes

Noni contains alkaloids, flavonoids, tripertinoid, protein, lime, iron, carotene, glycosides antarkiron. The content of anthraquinin, scaloptin, flavonoid and adaptogen compounds are active that have antifungal antimicrobial effects. antibiotics commonly used such as tetracycline, clindamycin others. These chemical-based antibacterials many negative side effects, therefore other alternatives needed antibacterials, one which is by using noni. This study aims to analyze bioautography determine the antibacterial activity noni leaf ethanol extract against Propionibacterium acnes bacteria.This research was conducted experimentally with concentrations 30%, 40%, 50% independent variables bioautographic analysis dependent variables. performed TLC test paper discs.The results testing a concentration 30% had an inhibition zone 8.36 mm medium category, 40% 10.3 strong category 11.1 in category. positive control tetracycline 30µg 20.8 categorized very strong. contact mobile phase chloroform: n-hexane (7:3). obtained at Rf value 0.17, characteristics chromatogram spots were carried out spraying 10% FeCl3 suspected compounds.